Cannabis use has increased significantly in recent years, and it has some experts concerned.
The use of cannabis can lead to changes in DNA that can cause genetic mutations and subsequent serious diseases, according to a new study.
Cannabis—also known as marijuana—is one of the most commonly used drugs in the United States. Its use has increased significantly in recent years, with a recent survey showing 42.3 million people used it in the past month.
The increased use of marijuana has some experts concerned.
The Health Risks of Cannabis Use
The study, published in Molecular Psychiatry, analyzed data from about 9,500 participants from different groups, including parents and children, twins, and older adults.
Researchers assessed DNA methylation, an indicator of potential health outcomes due to how genes are expressed. The genome study analyses were evaluated according to the different genetic groups and adjusted according to age, gender, cigarette smoking, and blood type.
Researchers found that five genes with DNA methylation had sites associated with the use of cannabis, with significant roles in human health conditions. This included one gene (LINC01132) linked to liver cancer and ovarian cancer. A previous study, however, showed a lower incidence of liver cancer among cannabis users.
Researchers also found that chemicals in cannabis, including the active ingredient THC (tetrahydrocannabinol), alter the user’s DNA, which can cause gene mutations that can increase the risks of diseases.
Understanding DNA Methylation
DNA methylation is a fundamental epigenetic mechanism that regulates gene expression without altering the underlying DNA sequence.
Methylation patterns can be heritable and change over time in response to various environmental factors, including diet, lifestyle, and substance exposure.
Altered DNA methylation patterns have been associated with several diseases and conditions, including cancer, developmental disorders, and neurological conditions. Factors such as aging, environmental exposures, and certain medications can influence DNA methylation patterns, potentially impacting gene regulation and cellular functions.
Research into DNA methylation continues to uncover its role in various biological processes and diseases, offering insights into potential therapeutic interventions and diagnostic strategies.
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